Nobuyuki Udagawa Selected Research

Bone Resorption

3/2022	Inhibitor of protein kinase N3 suppresses excessive bone resorption in ovariectomized mice.
1/2022	Evidence for the major contribution of remodeling-based bone formation in sclerostin-deficient mice.
1/2021	Osteoclast differentiation by RANKL and OPG signaling pathways.
11/2020	The Vitamin D Receptor in Osteoblast-Lineage Cells Is Essential for the Proresorptive Activity of 1α,25(OH)2D3 In Vivo.
1/2019	Regulation of osteoclast function via Rho-Pkn3-c-Src pathways.
1/2018	Mechanisms involved in bone resorption regulated by vitamin D.
8/2017	Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling.
6/2017	VDR in Osteoblast-Lineage Cells Primarily Mediates Vitamin D Treatment-Induced Increase in Bone Mass by Suppressing Bone Resorption.
7/2016	The dynamin inhibitor dynasore inhibits bone resorption by rapidly disrupting actin rings of osteoclasts.
4/2016	Regulation of bone metabolism by Wnt signals.

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Nobuyuki Udagawa Research Topics

Disease

33	Bone Resorption 03/2022 - 01/2002
14	Osteoporosis 01/2022 - 12/2003
5	Inflammation (Inflammations) 11/2021 - 09/2005
4	Hypercalcemia (Milk Alkali Syndrome) 11/2020 - 02/2007
4	Periodontitis 01/2017 - 02/2012
4	Rheumatoid Arthritis 02/2012 - 02/2002
3	Alveolar Bone Loss 01/2022 - 02/2013
3	Neoplasms (Cancer) 10/2015 - 01/2009
2	Bone Diseases (Bone Disease) 01/2022 - 02/2013
2	Body Weight (Weight, Body) 11/2020 - 02/2012
2	Necrosis 05/2016 - 11/2013
2	Fibrosis (Cirrhosis) 05/2016 - 05/2016
2	Cardiomegaly (Heart Hypertrophy) 05/2016 - 05/2016
2	Heart Failure 05/2016 - 05/2016
1	Type 2 Diabetes Mellitus (MODY) 01/2022
1	Aortic Dissection 01/2022
1	Aortic Rupture 01/2022
1	Periodontal Diseases (Periodontal Disease) 01/2022
1	Hypertension (High Blood Pressure) 01/2022
1	Osteolysis 10/2020
1	Colitis 01/2020
1	Infections 01/2020
1	Hyperostosis corticalis deformans juvenilis 09/2019
1	Scoliosis 10/2018
1	Ventricular Remodeling 05/2016
1	Left Ventricular Dysfunction 05/2016
1	Hypertrophy 05/2016
1	Glioma (Gliomas) 10/2015
1	Wilms Tumor (Wilm's Tumor) 10/2015
1	Osteonecrosis (Kienbock's Disease) 09/2015
1	Communicable Diseases (Infectious Diseases) 07/2014
1	Muscle Cramp (Cramp) 11/2013
1	Hearing Loss (Hearing Impairment) 03/2011
1	T-Cell Leukemia (Leukemia, T Cell) 10/2009

Drug/Important Bio-Agent (IBA)

11	OsteoprotegerinIBA 01/2022 - 12/2003
10	LigandsIBA 05/2016 - 01/2002
6	RANK LigandIBA 01/2022 - 01/2002
6	hydroxide ionIBA 11/2020 - 02/2007
6	Diphosphonates (Bisphosphonates)IBA 01/2016 - 02/2003
5	Pharmaceutical PreparationsIBA 01/2019 - 07/2009
4	CalciumIBA 01/2022 - 07/2006
3	eldecalcitol (ED 71)IBA 11/2020 - 02/2012
3	Vitamin D FDA LinkGeneric 01/2018 - 01/2014
3	Peptides (Polypeptides)IBA 01/2017 - 02/2013
3	LipopolysaccharidesIBA 11/2013 - 09/2005
3	Receptor Activator of Nuclear Factor-kappa B (TRANCE-R)IBA 10/2009 - 01/2002
2	protein kinase NIBA 03/2022 - 08/2017
2	Parathyroid Hormone (Parathormone)IBA 01/2022 - 10/2020
2	Angiotensin IIIBA 01/2022 - 05/2016
2	ProcollagenIBA 05/2016 - 05/2016
2	Matrix Metalloproteinases (MMPs)IBA 05/2016 - 06/2006
2	Biological ProductsIBA 05/2016 - 07/2006
2	CathelicidinsIBA 07/2014 - 11/2013
2	CytokinesIBA 06/2014 - 02/2002
2	Messenger RNA (mRNA)IBA 11/2013 - 02/2008
2	Dinoprostone (PGE2)FDA Link 11/2013 - 06/2005
2	Risedronic Acid (Actonel)FDA LinkGeneric 02/2013 - 12/2003
2	Neutralizing AntibodiesIBA 08/2011 - 07/2009
2	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 02/2008 - 07/2005
2	Acetylmuramyl-Alanyl-IsoglutamineIBA 02/2006 - 09/2005
1	PeriostinIBA 01/2022
1	C-Reactive ProteinIBA 01/2022
1	Alendronate (Alendronate Sodium)FDA LinkGeneric 01/2022
1	ElastinIBA 01/2022
1	Monoclonal AntibodiesIBA 11/2021
1	Fibroblast Growth Factor-23IBA 11/2020
1	Collagen Type I (Type I Collagen)IBA 11/2020
1	IsotopesIBA 10/2020
1	Immunoglobulins (Immunoglobulin)IBA 01/2020
1	Type 1 Angiotensin ReceptorIBA 09/2019
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2019
1	olfactomedinIBA 10/2018
1	N'- (3,4- dihydroxybenzylidene)- 3- hydroxy- 2- naphthahydrazideIBA 07/2016
1	Dynamins (Dynamin)IBA 07/2016
1	Syndecan-1 (Syndecan 1)IBA 05/2016
1	AntigensIBA 10/2015
1	PicibanilIBA 10/2015
1	VaccinesIBA 10/2015
1	alfacalcidolIBA 01/2014
1	Calcitriol (Calcijex)FDA LinkGeneric 01/2014
1	Cholecalciferol (Vitamin D3)FDA Link 01/2014
1	Formyl Peptide Receptors (Formyl Peptide Receptor)IBA 11/2013
1	Antimicrobial PeptidesIBA 11/2013
1	FlagellinIBA 11/2013
1	Phosphatidylinositols (Phosphatidylinositol)IBA 05/2012
1	TetracyclinesIBA 02/2012
1	VitaminsIBA 02/2012
1	Denosumab FDA Link 08/2011
1	2-methylene-1,25-dihydroxy-19-norvitamin D3IBA 08/2010
1	alisol BIBA 08/2010
1	Proteins (Proteins, Gene)FDA Link 10/2009
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2009
1	Interleukin-6 (Interleukin 6)IBA 10/2009

Therapy/Procedure

3	Therapeutics 01/2022 - 09/2015
1	Aftercare (After-Treatment) 01/2022
1	Subcutaneous Infusions 05/2016
1	Subcutaneous Injections 05/2016
1	Immunotherapy 10/2015
1	Drug Therapy (Chemotherapy) 10/2015
1	Lasers (Laser) 03/2011